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5.3.1.2 Microglia and AD The pathological significance of activated microglia in the brains of AD patients was first systematically described by McGeer and colleagues in 1987, a discovery that ignited extensive investigation into their potential role in neurodegenerative progression

Higher compression factors for smaller file sizes can be achieved with lossy compression, which reduces the precision and introduces rounding errors

Oxygen-derived molecules, such as superoxide and hydrogen peroxide, that can act as signals at physiological levels but become damaging when excessive

In human clinical use, reported side effects are generally mild and transient: Mild injection site redness or discomfort (resolves within hours) Transient nausea in some patients, particularly early in the protocol Mild dizziness or light-headedness (rare, typically dose-related) Temporary fatigue in the first few days (often a sign of active tissue remodeling) No significant systemic toxicity, organ damage, hormonal suppression, or addiction potential has been documented in the published literature